DIFFUSE WELL DIFFERENTIATED LYMPHOCYTIC LYMPHOMA
\dɪfjˈuːz wˈɛl dˌɪfəɹˈɛnʃɪˌe͡ɪtɪd lˌɪmfəsˈɪtɪk lɪmfˈə͡ʊmə], \dɪfjˈuːz wˈɛl dˌɪfəɹˈɛnʃɪˌeɪtɪd lˌɪmfəsˈɪtɪk lɪmfˈəʊmə], \d_ɪ_f_j_ˈuː_z w_ˈɛ_l d_ˌɪ_f_ə_ɹ_ˈɛ_n_ʃ_ɪ__ˌeɪ_t_ɪ_d l_ˌɪ_m_f_ə_s_ˈɪ_t_ɪ_k l_ɪ_m_f_ˈəʊ_m_ə]\
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A low-grade malignant lymphoma that may, in some cases, be considered histologically identical to chronic lymphocytic leukemia (CLL; LEUKEMIA, LYMPHOCYTIC, CHRONIC). It is diffuse in pattern, representing the neoplastic proliferation of well-differentiated B-lymphocytes. In patients with immunoglobulin gammopathies, the lymphocytes may exhibit plasmacytoid characteristics.
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Sporadic Retinoblastoma
- A malignant arising nuclear layer retina that is most primary eye in children. The tumor tends to occur early childhood or infancy present at birth. majority are sporadic, but condition may be transmitted as autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS; STRABISMUS; visual loss represent common clinical characteristics this condition. (From DeVita et al., Cancer: Principles Practice Oncology, 5th ed, p2104)