DIFFUSE IMMUNOBLASTIC LYMPHOSARCOMAS
\dɪfjˈuːz ɪmjˌuːnə͡ʊblˈastɪk lˌɪmfəsɑːkˈə͡ʊməz], \dɪfjˈuːz ɪmjˌuːnəʊblˈastɪk lˌɪmfəsɑːkˈəʊməz], \d_ɪ_f_j_ˈuː_z ɪ_m_j_ˌuː_n_əʊ_b_l_ˈa_s_t_ɪ_k l_ˌɪ_m_f_ə_s_ɑː_k_ˈəʊ_m_ə_z]\
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Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
- diffuse globoid body sclerosis
- diffuse histiocytic lymphoma
- diffuse histiocytic lymphomas
- diffuse idiopathic skeletal hyperostosis
- diffuse immunoblastic lymphosarcoma
- Diffuse Immunoblastic Lymphosarcomas
- diffuse inflammation
- diffuse large cell lymphoma
- diffuse large cell lymphomas
- diffuse large follicular center cell lymphoma
- diffuse lesion