DECEREBRATE RIGIDITY
\dɪsˈɜːɹɪbɹˌe͡ɪt ɹɪd͡ʒˈɪdɪti], \dɪsˈɜːɹɪbɹˌeɪt ɹɪdʒˈɪdɪti], \d_ɪ_s_ˈɜː_ɹ_ɪ_b_ɹ_ˌeɪ_t ɹ_ɪ_dʒ_ˈɪ_d_ɪ_t_i]\
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A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.