CYCLIN DEPENDENT KINASE INHIBITOR 2A
\sˈa͡ɪklɪn dɪpˈɛndənt kˈɪne͡ɪs ɪnhˈɪbɪtə tˈuː ˈe͡ɪ], \sˈaɪklɪn dɪpˈɛndənt kˈɪneɪs ɪnhˈɪbɪtə tˈuː ˈeɪ], \s_ˈaɪ_k_l_ɪ_n d_ɪ_p_ˈɛ_n_d_ə_n_t k_ˈɪ_n_eɪ_s ɪ_n_h_ˈɪ_b_ɪ_t_ə t_ˈuː ˈeɪ]\
Definitions of CYCLIN DEPENDENT KINASE INHIBITOR 2A
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A gene product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member the INK4 family - inhibitors of cyclin-dependent kinase CDK4. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is P14ARF PROTEIN. Both p16 gene products have tumor suppressor functions.
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bcr v abl Oncogene
- Retrovirus-associated DNA sequences (abl) originally isolated from Abelson murine leukemia virus (Ab-MuLV). proto-oncogene abl (codes for a protein that member tyrosine kinase family. human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It activated by translocation to bcr 22 in chronic myelogenous leukemia.