CYCLIN DEPENDENT KINASE 1
\sˈa͡ɪklɪn dɪpˈɛndənt kˈɪne͡ɪs wˈɒn], \sˈaɪklɪn dɪpˈɛndənt kˈɪneɪs wˈɒn], \s_ˈaɪ_k_l_ɪ_n d_ɪ_p_ˈɛ_n_d_ə_n_t k_ˈɪ_n_eɪ_s w_ˈɒ_n]\
Definitions of CYCLIN DEPENDENT KINASE 1
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Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the cell cycle. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of p34cdc2 is achieved when it is fully dephosphorylated. Protein p34cdc2, the product of the cdc2 gene in Schizosaccharomyces pombe, should not be confused with the unrelated product of the CDC2 gene in Saccharomyces cerevisiae that forms the large subunit of DNA polymerase III.
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bcr v abl Oncogene
- Retrovirus-associated DNA sequences (abl) originally isolated from Abelson murine leukemia virus (Ab-MuLV). proto-oncogene abl (codes for a protein that member tyrosine kinase family. human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It activated by translocation to bcr 22 in chronic myelogenous leukemia.