CRIPPLEWARE

\kɹˈɪpluːˌe͡ə], \kɹˈɪpluːˌe‍ə], \k_ɹ_ˈɪ_p_l_uː_ˌeə]\
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1985 - The Free On-line Dictionary of Computing
By Denis Howe

Word of the day

ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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