CRANIORACHISCHISES
\kɹˈani͡əɹˌakɪst͡ʃˌa͡ɪzɪz], \kɹˈaniəɹˌakɪstʃˌaɪzɪz], \k_ɹ_ˈa_n_iə_ɹ_ˌa_k_ɪ_s_tʃ_ˌaɪ_z_ɪ_z]\
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Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
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