CRANIAL ARTERITIS
\kɹˈe͡ɪnɪəl ˌɑːtəɹˈa͡ɪtɪs], \kɹˈeɪnɪəl ˌɑːtəɹˈaɪtɪs], \k_ɹ_ˈeɪ_n_ɪ__ə_l ˌɑː_t_ə_ɹ_ˈaɪ_t_ɪ_s]\
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A systemic autoimmune vasculitis occurring primarily in people over the age of 50. Pathologic features include a necrotizing panarteritis including granulomas and giant cells. There is a predilection for involvement of central nervous system blood vessels and the most frequent neurologic complication is an OPTIC NEUROPATHY, ISCHEMIC. Large blood vessels may become involved, including the aorta. Clinical manifestations may include myalgias, weight loss, headache, visual loss, necrosis of the skin or tongue, and chest discomfort. Superficial scalp arteries may become tender and enlarged. A related condition, juvenile temporal arteritis, tends to occur in the first or second decade of life. (From Adams et al., Principles of Neurology, 6th ed, p856)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.