CRANIAL EPIDURAL ABSCESS
\kɹˈe͡ɪnɪəl ˈɛpɪdjˌʊ͡əɹə͡l ˈabsɛs], \kɹˈeɪnɪəl ˈɛpɪdjˌʊəɹəl ˈabsɛs], \k_ɹ_ˈeɪ_n_ɪ__ə_l ˈɛ_p_ɪ_d_j_ˌʊə_ɹ_əl ˈa_b_s_ɛ_s]\
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Circumscribed collections of suppurative material occurring in the spinal or intracranial EPIDURAL SPACE. The majority of epidural abscesses occur in the spinal canal and are associated with OSTEOMYELITIS of a vertebral body; ANALGESIA, EPIDURAL; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, URINARY INCONTINENCE, and FECAL INCONTINENCE. Cranial epidural abscesses are usually associated with OSTEOMYELITIS of a cranial bone, SINUSITIS, or OTITIS MEDIA. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65 (2):209-12)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.