CONVERGENCE EXCESSES

\kənvˈɜːd͡ʒəns ɛksˈɛsɪz], \kənvˈɜːd‍ʒəns ɛksˈɛsɪz], \k_ə_n_v_ˈɜː_dʒ_ə_n_s ɛ_k_s_ˈɛ_s_ɪ_z]\

Definitions of CONVERGENCE EXCESSES

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2010 - Medical Dictionary Database
By DataStellar Co., Ltd

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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