CONVENTIONER

\kənvˈɛnʃənə], \kənvˈɛnʃənə], \k_ə_n_v_ˈɛ_n_ʃ_ə_n_ə]\
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1874 - Etymological and pronouncing dictionary of the English language
By Stormonth, James, Phelp, P. H.

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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