CONTINUOUS MUSCLE ACTIVITY SYNDROME
\kəntˈɪnjuːəs mˈʌsə͡l aktˈɪvɪti sˈɪndɹə͡ʊm], \kəntˈɪnjuːəs mˈʌsəl aktˈɪvɪti sˈɪndɹəʊm], \k_ə_n_t_ˈɪ_n_j_uː_ə_s m_ˈʌ_s_əl a_k_t_ˈɪ_v_ɪ_t_i s_ˈɪ_n_d_ɹ_əʊ_m]\
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A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.