CONGOPHILIC ANGIOPATHIES
\kɒnɡəfˈɪlɪk ˌaŋɡɪˈɒpəθɪz], \kɒnɡəfˈɪlɪk ˌaŋɡɪˈɒpəθɪz], \k_ɒ_n_ɡ_ə_f_ˈɪ_l_ɪ_k ˌa_ŋ_ɡ_ɪ__ˈɒ_p_ə_θ_ɪ_z]\
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A heterogeneous group of disorders that includes sporadic and familial forms, characterized clinically by cerebral ischemia (see BRAIN ISCHEMIA), CEREBRAL INFARCTION, and CEREBRAL HEMORRHAGE. Pathologically the condition is marked by the deposition of AMYLOID in the walls of small blood vessels in the cerebral cortex and meninges. The sporadic form is associated with lobar cerebral hemorrhage in the elderly and ALZHEIMER DISEASE. (From Neuropathol Appl Neurobiol 1996 Jun;22 (3):216-227; Adams et al., Principles of Neurology, 6th ed, p852)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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