CONFLUXIBILITY

\kˌɒnfləksɪbˈɪlɪti], \kˌɒnfləksɪbˈɪlɪti], \k_ˌɒ_n_f_l_ə_k_s_ɪ_b_ˈɪ_l_ɪ_t_i]\
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1914 - Nuttall's Standard dictionary of the English language
By Nuttall, P.Austin.

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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