COMPLEMENTARITY DETERMINING REGION II
\kˌɒmplɪməntˈaɹɪti dɪtˈɜːmɪnɪŋ ɹˈiːd͡ʒən ɹˌə͡ʊmən tˈuː], \kˌɒmplɪməntˈaɹɪti dɪtˈɜːmɪnɪŋ ɹˈiːdʒən ɹˌəʊmən tˈuː], \k_ˌɒ_m_p_l_ɪ_m_ə_n_t_ˈa_ɹ_ɪ_t_i d_ɪ_t_ˈɜː_m_ɪ_n_ɪ_ŋ ɹ_ˈiː_dʒ_ə_n ɹ_ˌəʊ_m_ə_n_ t_ˈuː]\
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Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
- complementarity determining region
- complementarity determining region 1
- complementarity determining region 2
- complementarity determining region 3
- complementarity determining region i
- Complementarity Determining Region II
- complementarity determining region iii
- complementarity determining regions
- complementary
- complementary angles
- complementary color