COMPLEMENT 1 INACTIVATORS
\kˈɒmplɪmənt wˈɒn ɪnˈaktɪvˌe͡ɪtəz], \kˈɒmplɪmənt wˈɒn ɪnˈaktɪvˌeɪtəz], \k_ˈɒ_m_p_l_ɪ_m_ə_n_t w_ˈɒ_n ɪ_n_ˈa_k_t_ɪ_v_ˌeɪ_t_ə_z]\
Definitions of COMPLEMENT 1 INACTIVATORS
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Compounds which inhibit, antagonize, or inactivate complement 1. A well-known inhibitor is a serum glycoprotein believed to be alpha-2-neuroaminoglycoprotein. It inhibits the activated (esterase) form of complement 1 as well as kinin-forming, coagulation, and fibrinolytic systems. Deficiency of this inactivator has been found in patients with hereditary angioneurotic edema. These compounds are members of the serpin superfamily.
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Marcy, Randolph B.
- (1812-1887), served Mexican War, and brevetted major-general for services during Civil War. From 1869 to 1881 he was inspector-general. published "Exploration of the Red River" in 1852.