COLONY STIMULATING FACTOR 1
\kˈɒlənɪ stˈɪmjʊlˌe͡ɪtɪŋ fˈaktə wˈɒn], \kˈɒlənɪ stˈɪmjʊlˌeɪtɪŋ fˈaktə wˈɒn], \k_ˈɒ_l_ə_n_ɪ s_t_ˈɪ_m_j_ʊ_l_ˌeɪ_t_ɪ_ŋ f_ˈa_k_t_ə w_ˈɒ_n]\
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A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
- colony forming units assay, tumor
- colony forming units assays
- colony forming units, erythroid
- colony forming units, hematopoietic
- colony stimulating factor
- Colony Stimulating Factor 1
- colony stimulating factor 2 alpha
- colony stimulating factor receptor
- colony stimulating factor receptors
- colony stimulating factor, macrophage
- colony stimulating factor, mast cell