COGWHEEL RIGIDITIES
\kˈɒɡwiːl ɹɪd͡ʒˈɪdɪtiz], \kˈɒɡwiːl ɹɪdʒˈɪdɪtiz], \k_ˈɒ_ɡ_w_iː_l ɹ_ɪ_dʒ_ˈɪ_d_ɪ_t_i_z]\
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Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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