CLAUDE BERNARD HORNER SYNDROME
\klˈɔːd bˈɜːnəd hˈɔːnə sˈɪndɹə͡ʊm], \klˈɔːd bˈɜːnəd hˈɔːnə sˈɪndɹəʊm], \k_l_ˈɔː_d b_ˈɜː_n_ə_d h_ˈɔː_n_ə s_ˈɪ_n_d_ɹ_əʊ_m]\
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A syndrome associated with defective sympathetic innervation to one side of the face, including the eye. Clinical features include MIOSIS; mild BLEPHAROPTOSIS; and hemifacial ANHIDROSIS (decreased sweating) (see HYPOHIDROSIS). Lesions of the BRAIN STEM; cervical SPINAL CORD; first thoracic nerve root; apex of the LUNG; CAROTID ARTERY; CAVERNOUS SINUS; and apex of the ORBIT may cause this condition. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp500-11)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.