CLATHRIN COATED VESICLES
\klˈaθɹɪn kˈə͡ʊtɪd vˈɛsɪkə͡lz], \klˈaθɹɪn kˈəʊtɪd vˈɛsɪkəlz], \k_l_ˈa_θ_ɹ_ɪ_n k_ˈəʊ_t_ɪ_d v_ˈɛ_s_ɪ_k_əl_z]\
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Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as ENDOSOMES.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.