CLASSICAL ANTIHISTAMINICS
\klˈasɪkə͡l ˌantɪhˌɪstɐmˈɪnɪks], \klˈasɪkəl ˌantɪhˌɪstɐmˈɪnɪks], \k_l_ˈa_s_ɪ_k_əl ˌa_n_t_ɪ_h_ˌɪ_s_t_ɐ_m_ˈɪ_n_ɪ_k_s]\
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Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
By DataStellar Co., Ltd
