CLASSIC MAPLE SYRUP URINE DISEASE
\klˈasɪk mˈe͡ɪpə͡l sˈɪɹʌp jˈʊ͡əɹɪn dɪzˈiːz], \klˈasɪk mˈeɪpəl sˈɪɹʌp jˈʊəɹɪn dɪzˈiːz], \k_l_ˈa_s_ɪ_k m_ˈeɪ_p_əl s_ˈɪ_ɹ_ʌ_p j_ˈʊə_ɹ_ɪ_n d_ɪ_z_ˈiː_z]\
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An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain ammino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a "maple syrup" odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)
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Word of the day
tinctura quininae ammoniata
- A preparation made by dissolving quinin sulphate in alcohol [Br. Ph.].