CIRCUMSCRIBED NEURODERMATITIS
\sˈɜːkəmskɹˌa͡ɪbd njˌuːɹə͡ʊdəmɐtˈa͡ɪtɪs], \sˈɜːkəmskɹˌaɪbd njˌuːɹəʊdəmɐtˈaɪtɪs], \s_ˈɜː_k_ə_m_s_k_ɹ_ˌaɪ_b_d n_j_ˌuː_ɹ_əʊ_d_ə_m_ɐ_t_ˈaɪ_t_ɪ_s]\
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An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.