CI898
\sˈa͡ɪ ˈe͡ɪthˈʌndɹədən nˈa͡ɪntiˈe͡ɪt], \sˈaɪ ˈeɪthˈʌndɹədən nˈaɪntiˈeɪt], \s_ˈaɪ ˈeɪ_t_h_ˈʌ_n_d_ɹ_ə_d_ə_n n_ˈaɪ_n_t_i__ˈeɪ_t]\
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A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against Pneumocystis carinii pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.