CHROMOSOME WALKINGS
\kɹˈə͡ʊməsˌə͡ʊm wˈɔːkɪŋz], \kɹˈəʊməsˌəʊm wˈɔːkɪŋz], \k_ɹ_ˈəʊ_m_ə_s_ˌəʊ_m w_ˈɔː_k_ɪ_ŋ_z]\
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A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.