CHOLANGIOCARCINOMA
\t͡ʃˌɒlɐŋɡɪˌɒkɑːsɪnˈə͡ʊmə], \tʃˌɒlɐŋɡɪˌɒkɑːsɪnˈəʊmə], \tʃ_ˌɒ_l_ɐ_ŋ_ɡ_ɪ__ˌɒ_k_ɑː_s_ɪ_n_ˈəʊ_m_ə]\
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A malignant tumor arising from the intrahepatic bile duct epithelium. It is composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant stroma. (From Holland et al., Cancer Medicine, 3d ed, p1455; Stedman, 25th ed)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.