CHLOROGUANIDE
\klˌɔːɹə͡ʊɡjˈuːɐnˌa͡ɪd], \klˌɔːɹəʊɡjˈuːɐnˌaɪd], \k_l_ˌɔː_ɹ_əʊ_ɡ_j_ˈuː_ɐ_n_ˌaɪ_d]\
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A biguanide compound which has little antimalarial activity until metabolized in the body to the active antimalarial agent cycloguanil. The usefulness of proguanil is limited by the rapid development of drug resistance by the malarial parasite. The hydrochloride is used for the casual prophylaxis of falciparum malaria, to suppress other forms of malaria, and to reduce transmission of infection (From Martindale, The Extra Pharmacopoeia, 30th ed, p405)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.