CEREBELLAR ATAXIA
\sˈɛɹɪbˌɛləɹ atˈe͡ɪksi͡ə], \sˈɛɹɪbˌɛləɹ atˈeɪksiə], \s_ˈɛ_ɹ_ɪ_b_ˌɛ_l_ə_ɹ a_t_ˈeɪ_k_s_iə]\
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Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of rapidly alternating movements (adiadochokinesis), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.