CARDIOTOXIN I
\kˈɑːdɪˌə͡ʊtəksˌɪn ˈa͡ɪ], \kˈɑːdɪˌəʊtəksˌɪn ˈaɪ], \k_ˈɑː_d_ɪ__ˌəʊ_t_ə_k_s_ˌɪ_n ˈaɪ]\
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Most abundant proteins in cobra (Naja of the Elapids) venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contracture, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis. Synonyms: cobramine A; cobramine B; cobra cytotoxin; gamma toxin; membrane-active polypeptide.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.