CAPABILITY BROWN
\kˌe͡ɪpəbˈɪlɪti bɹˈa͡ʊn], \kˌeɪpəbˈɪlɪti bɹˈaʊn], \k_ˌeɪ_p_ə_b_ˈɪ_l_ɪ_t_i b_ɹ_ˈaʊ_n]\
Word of the day
ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.