Definitions of C1 Inactivators

  1. Compounds which inhibit, antagonize, or inactivate complement 1. A well- known inhibitor is a serum glycoprotein believed to be alpha- 2- neuroaminoglycoprotein. It inhibits the activated ( esterase) form of complement 1 as well as kinin- forming, coagulation, and fibrinolytic systems. Deficiency of this inactivator has been found in patients with hereditary angioneurotic edema. These compounds are members of the serpin superfamily.