Definitions of c myc Proto Oncogene

  1. Family of retrovirus- associated DNA sequences ( myc) originally isolated from an avian myelocytomatosis virus. The proto- oncogene myc ( c- myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c- myc expression, is crucial for tumorigenicity. The human c- myc gene is located at 8q24 on the long arm of chromosome 8.