Definitions of c myb Proto Oncogenes
Retrovirus- associated DNA sequences ( v- myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto- oncogene c- myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22- 23 on the short arm of chromosome 6. This is the point of break in translocations involved in T- cell acute lymphatic leukemia and in some ovarian cancers and melanomas. ( From Ibelgaufts, Dictionary of Cytokines, 1995).