C MYB PROTO ONCOGENE
\sˈiː mˈɪb pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːn], \sˈiː mˈɪb pɹˈəʊtəʊ ˈɒnkəʊdʒˌiːn], \s_ˈiː m_ˈɪ_b p_ɹ_ˈəʊ_t_əʊ ˈɒ_n_k_əʊ_dʒ_ˌiː_n]\
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Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).
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