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Definitions of c kit Protein

  1. A protein- tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO- ONCOGENE PROTEIN C- KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c- kit protein- tyrosine kinase is associated with tumorigenesis. EC 2. 7. 11.-.
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