Definitions of c fos Proto Oncogenes

  1. Retrovirus- associated DNA sequences ( fos) originally isolated from the Finkel- Biskis- Jinkins ( FBJ- MSV) and Finkel- Biskis- Reilly ( FBR- MSV) murine sarcoma viruses. The proto- oncogene protein c- fos codes for a nuclear protein which is involved in growth- related transcriptional control. The insertion of c- fos into FBJ- MSV or FBR- MSV induces osteogenic sarcomas in mice. The human c- fos gene is located at 14q21- 31 on the long arm of chromosome 14.