C FMS PROTO ONCOGENES
\sˈiː ˌɛfˌɛmˈɛs pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːnz], \sˈiː ˌɛfˌɛmˈɛs pɹˈəʊtəʊ ˈɒnkəʊdʒˌiːnz], \s_ˈiː_ ˌɛ_f_ˌɛ_m_ˈɛ_s p_ɹ_ˈəʊ_t_əʊ ˈɒ_n_k_əʊ_dʒ_ˌiː_n_z]\
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Family of genes originally isolated from the Susan McDonough strain of feline sarcoma virus (SARCOMA VIRUSES, FELINE). The proto-oncogene fms (c-fms) codes for the MCSF receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR). The oncogene fms (v-fms) codes for ONCOGENE PROTEIN GP1409 (V-FMS) which is a mutated form of the MCSF. The human c-fms gene is located between 5q33.2 and 5q33.3.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.