C ABL PROTEINS
\sˈiː ˈabə͡l pɹˈə͡ʊtiːnz], \sˈiː ˈabəl pɹˈəʊtiːnz], \s_ˈiː_ ˈa_b_əl p_ɹ_ˈəʊ_t_iː_n_z]\
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Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
By DataStellar Co., Ltd
Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.