BRONCHIOLOALVEOLAR CARCINOMA
\bɹˌɒnkɪˌɒlə͡ʊlvɪˈə͡ʊlə kˌɑːsɪnˈə͡ʊmə], \bɹˌɒnkɪˌɒləʊlvɪˈəʊlə kˌɑːsɪnˈəʊmə], \b_ɹ_ˌɒ_n_k_ɪ__ˌɒ_l_əʊ_l_v_ɪ__ˈəʊ_l_ə k_ˌɑː_s_ɪ_n_ˈəʊ_m_ə]\
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A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.