BRCA2 GENES
\bˌiːˌɑːsˌiːˈe͡ɪ tˈuː d͡ʒˈiːnz], \bˌiːˌɑːsˌiːˈeɪ tˈuː dʒˈiːnz], \b_ˌiː__ˌɑː_s_ˌiː__ˈeɪ t_ˈuː dʒ_ˈiː_n_z]\
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A tumor suppressor gene (GENES, SUPPRESSOR, TUMOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14 (11):1400-6)
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