BONE AND BONES
\bˈə͡ʊn and bˈə͡ʊnz], \bˈəʊn and bˈəʊnz], \b_ˈəʊ_n a_n_d b_ˈəʊ_n_z]\
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A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS, OSTEOCYTES and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydoxyapatite crystals form the BONE MATRIX.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.