BIOLOGIC TUMOR MARKERS
\bˌa͡ɪəlˈɒd͡ʒɪk tjˈuːmə mˈɑːkəz], \bˌaɪəlˈɒdʒɪk tjˈuːmə mˈɑːkəz], \b_ˌaɪ_ə_l_ˈɒ_dʒ_ɪ_k t_j_ˈuː_m_ə m_ˈɑː_k_ə_z]\
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Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.