BIG APPLE
\bˈɪɡ ˈapə͡l], \bˈɪɡ ˈapəl], \b_ˈɪ_ɡ ˈa_p_əl]\
Definitions of BIG APPLE
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Sporadic Retinoblastoma
- A malignant arising nuclear layer retina that is most primary eye in children. The tumor tends to occur early childhood or infancy present at birth. majority are sporadic, but condition may be transmitted as autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS; STRABISMUS; visual loss represent common clinical characteristics this condition. (From DeVita et al., Cancer: Principles Practice Oncology, 5th ed, p2104)