BIFUNCTIONAL ANTIBODIES
\ba͡ɪfˈʌŋkʃənə͡l ˈantɪbˌɒdɪz], \baɪfˈʌŋkʃənəl ˈantɪbˌɒdɪz], \b_aɪ_f_ˈʌ_ŋ_k_ʃ_ə_n_əl ˈa_n_t_ɪ_b_ˌɒ_d_ɪ_z]\
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Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate antigenic determinants. They are artificial antibodies produced by chemical crosslinking, fusion of hybridoma cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
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- bifurcate
- bifurcate, bifurcated
- bifurcate.
- bifurcated