BETA 2 MICROGLOBULIN
\bˈiːtə tˈuː mˌa͡ɪkɹə͡ʊɡlˈɒbjʊlˌɪn], \bˈiːtə tˈuː mˌaɪkɹəʊɡlˈɒbjʊlˌɪn], \b_ˈiː_t_ə t_ˈuː m_ˌaɪ_k_ɹ_əʊ_ɡ_l_ˈɒ_b_j_ʊ_l_ˌɪ_n]\
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An 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.
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