BASE PAIR MISMATCHES
\bˈe͡ɪs pˈe͡ə mɪsmˈat͡ʃɪz], \bˈeɪs pˈeə mɪsmˈatʃɪz], \b_ˈeɪ_s p_ˈeə m_ɪ_s_m_ˈa_tʃ_ɪ_z]\
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The presence of an uncomplementary base in double-stranded DNA caused by spontaneous deamination of cytosine or adenine, mismatching during homologous recombination, or errors in DNA replication. Multiple, sequential base pair mismatches lead to formation of heteroduplex DNA; (NUCLEIC ACID HETERODUPLEXES).
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.