BACLOFEN RECEPTORS
\bˈaklə͡ʊfən ɹɪsˈɛptəz], \bˈakləʊfən ɹɪsˈɛptəz], \b_ˈa_k_l_əʊ_f_ə_n ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and influence cells via interactions with G-proteins. GABA-B receptors are pharmacologically characterized by their insensitivity to the blocker bicuculline and sensitivity to the agonist L-baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase A2, activation of potassium channels, and inactivation of voltage-activated calcium channels.
By DataStellar Co., Ltd
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