ATP BINDING CASSETTE, SUB FAMILY B PROTEINS
\ˌe͡ɪtˌiːpˈiː bˈa͡ɪndɪŋ kɐsˈɛt], \ˌeɪtˌiːpˈiː bˈaɪndɪŋ kɐsˈɛt], \ˌeɪ_t_ˌiː_p_ˈiː b_ˈaɪ_n_d_ɪ_ŋ k_ɐ_s_ˈɛ_t]\
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A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
By DataStellar Co., Ltd
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Nearby Words
- atp adp translocase
- atp adpase
- atp amp phosphotransferase
- atp amp transphosphorylase
- atp binding cassette transporters
- ATP Binding Cassette, Sub Family B Proteins
- atp binding cassette, sub family b, member 1
- atp binding cassette, sub family c proteins
- atp choline transphosphatase
- atp citrate (pro 3s) lyase
- atp citrate (pro s) lyase