\ɐtˈə͡ʊnɪk ˈʌlsə], \ɐtˈə‍ʊnɪk ˈʌlsə], \ɐ_t_ˈəʊ_n_ɪ_k ˈʌ_l_s_ə]\
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1920 - A practical medical dictionary.
By Stedman, Thomas Lathrop
1916 - Appleton's medical dictionary
By Smith Ely Jelliffe

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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