AT HOOK MOTIF
\at hˈʊk mə͡ʊtˈiːf], \at hˈʊk məʊtˈiːf], \a_t h_ˈʊ_k m_əʊ_t_ˈiː_f]\
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DNA-binding motifs, first described in one of the HMGA PROTEINS, HMG-I (Y). They consist of positively charged sequences of nine amino acids centered on the invariant tripeptide glycine-arginine-proline. They act to fasten the protein to an AT RICH SEQUENCE in the DNA.
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